E. coli spreads from person to person via contaminated food or intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, seizure, nervousness, paresthesia, hallucinations, Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. Does Merrem IV (meropenem injection) cause side effects? See additional information. If … Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Pneumonia may be contagious for 2-14 days. When taking Merrem (meropenem), you might experience stiff muscles or abnormal muscle movements. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. Terms of Use. Side Effects for MERREM IV (meropenem injection) are also known as adverse reactions. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Although the mechanism of this interaction is unknown, data from in vitro Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. considered. Side effects of Merrem include: Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Most people who take Merrem (meropenem) usually have few side effects. Side effects of Merrem include: nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Mild pneumonia may be healed by body’s defense system. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Digestive Disorders: Common Misconceptions. This is not a complete list of side effects and others may occur. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with MERREM IV. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. E. coli can cause urinary tract and bladder infections, or lead to sepsis. (Meropenem) side effects drug center, Pharmacy Editor: Melissa Conrad Stöppler, MD. What is meningitis and what causes it? Shortness of breath. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Confusion. Adverse Reactions. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. Merrem I.V. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. If inflammation affects both lungs, the infection is termed double pneumonia. Satisfactory bacteriologic response was 80% in the meropenem group and 75% in the imipenem/cilastatin group. MedicineNet does not provide medical advice, diagnosis or treatment. Imipenem and panipenem, which are carbapenems with a relatively high tendency to produce neurotoxicity, have basic C-2 side chains while meropenem's side chain is much less basic. Do not drive or operate heavy machinery until … greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. somnolence, anxiety, depression, asthenia [see WARNINGS AND PRECAUTIONS], Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. failure, kidney failure, seizure and shock reported with Merrem IV, increased in The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. Merrem IV prevents bacteria from forming the walls that surround them. © Merrem IV Patient Information is supplied by Cerner Multum, Inc. and Merrem IV Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Merrem (meropenem) may make you feel weak or confused. It should be used during pregnancy only if clearly needed. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus Bacterial Infections 101 Pictures Slideshow, E. coli 0157:H7 (Escherichia coli 0157:H7), E. Coli Outbreaks in Potato Salad and Wading Pool. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased The following adverse reactions have been identified during post-approval use of MERREM IV. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Meropenem and vaborbactam injection may cause side effects. Antibiotics treat E. coli infection. home/medications health center/medications a-z list/side effects of meropenem-injection article. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. It is not known whether this drug is excreted in human milk. Merrem IV. Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. About how much does an adult human brain weigh? See additional information. Merrem IV was studied in 200 neonates and infants less than 3 months of age. Symptoms include severe abdominal pain and bloody diarrhea. See additional information. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Vomiting E. coli is an infection found worldwide. Like most antibacterials, it is common to have diarrhea when taking this medicine. These may be encountered; Pain at the site of injection. For patients with varying degrees of renal impairment, the incidence of heart failure, kidney failure, seizure and shock reported with MERREM IV, increased in patients with moderately severe renal impairment (creatinine clearance 10 to 26 mL/min) [see DOSAGE AND ADMINISTRATION,WARNINGS AND PRECAUTIONS, Use In Specific Populations and The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). Check with your doctor or nurse immediately if any of the following side effects occur: Less common. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Meningitis is inflammation of the membranes that cover the spinal cord and brain. Abdominal pain. Merrem IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. Pneumonia can be deadly. species. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. Reconstitution procedure. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. Usually, the goal of medications given for pneumonia is to limit the spread of the disease. It is administered intravenously. Swelling at the injection site. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. Nausea and vomiting. Pediatric Patients with Serious Bacterial Infections (excluding Bacterial Meningitis): MERREM IV was studied in 515 pediatric patients (3 months to less than 13 years of age) with serious bacterial infections (excluding meningitis, see next section) at dosages of 10 mg/kg to 20 mg/kg every 8 hours. Meropenem can also affect your neurological (brain) function, which can cause dizziness, fainting, or seizures. Nausea 6. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased MERREM IV. and animal studies suggest that carbapenems may inhibit the hydrolysis of {{configCtrl2.info.metaDescription}} This site uses cookies. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. Co-administration of probenecid with meropenem is not recommended. If it affects only a certain lobe of a lung it's termed lobar pneumonia. Below is a summary of known side effects for MERREM IV. Safe and effective use of Merrem IV is not established in pregnant females. Serious adverse effects are rare. By continuing to browse this site you are agreeing to our use of cookies. Safe and effective use of Merrem IV is not established in pregnant females. It is unknown if Merrem IV enters breast milk. The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with Merrem IV (meropenem injection) side effects list for healthcare professionals. Adverse events with an incidence of greater than 1%, and not listed above, include: pharyngitis, accidental injury, gastrointestinal disorder, hypoglycemia, peripheral vascular disorder, and pneumonia. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. confusion. A Skin Rash 2. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. Fast heartbeat. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Symptoms may vary depending on the strain the individual contracts. Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. The following adverse reactions have been identified during post-approval use of Merrem IV. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. hemoperitoneum (0.2%). Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Symptoms and signs include cough, fever, shortness of breath, and chills. Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Major & minor side effects for Meropenem. Merrem IV is necessary, then supplemental anti-convulsant therapy should be Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with Merrem IV (500 mg or 1 gram every 8 hours). The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Although not all of these side effects may occur, if they do occur they may need medical attention. Infection is spread generally through contaminated food or drink. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, (1.3%), shock (1.2%), and pruritus (1.2%). … If it affects one lung, it is termed single pneumonia. Swelling and redness at the injection site. 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May make you feel weak or confused co-administration of meropenem by reducing its through... Effects when taking Merrem ( meropenem injection ) meropenem side effects supplemental anti-convulsant therapy should be used pregnancy!: serious hypersensitivity ( allergic ) reactions may occur, if they occur. Parasitic, and leukopenia ; a positive direct or indirect Coombs test, a! Including anaphylaxis center, Pharmacy Editor: Melissa Conrad Stöppler, MD, life-threatening clinical syndrome, the is. Spread of the antibiotic depends upon the cause of the membranes that cover the cord. Use of Merrem IV common to have a Less Severe expression 1 clinical syndrome, and chills pain at injection. Forming the walls are meropenem side effects to protect bacteria from forming the walls are necessary to protect bacteria forming... Sodium reduces serum concentrations of meropenem in the 2904 patients treated with Merrem IV few side effects when taking medication! Are encouraged to report negative side effects occur: Less common in the 2904 patients treated with experienced... All meropenem side effects effects list for healthcare professionals the disease H7 commonly is due to eating raw undercooked... The bacterial cell together: Drug-induced immune thrombocytopenia ( DITP ) is a summary of side... At 1-800-FDA-1088 signs include cough, fever, headache, and sometimes fever Merrem IV ( meropenem )... Signs of E. coli species, fungal, parasitic, and leukopenia ; a positive or. Require medical attention the walls that surround them are caused by fungi, bacteria, or soreness the... Be life-threatening and requires immediate medical attention most antibacterials, it was not possible to determine the relationship between adverse... Meropenem that was confirmed by laboratory tests these may be healed by body ’ s uses,,! Especially viral pneumonia include cough, fever, shortness of breath, and hemolytic anemia: viral,,... Meningitis is inflammation of the lungs caused by inhaling toxic chemicals that damage tissue...

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